Author

WANG XiaoDong

National Institute of Biological Sciences - Cited by 88,249 - medical sciences

Biography

Xiaodong Wang is the Director and an Investigator of the National Institute for Biological Sciences, Beijing. Previously, Dr. Wang was a professor of biochemistry at The University of Texas Southwestern Medical Center at Dallas and an investigator of the Howard Hughes Medical Institute from 1997-2010. Wang received a bachelor’s degree in biology from Beijing Normal University in Beijing, China, in 1984 and a doctorate degree in biochemistry from UT Southwestern in 1991.Wang’s laboratory’s research focuses on the cellular mechanisms that controls the life and death of animal cells.
Title
Cited by
Year
Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3
H Wang, L Sun, L Su, J Rizo, L Liu, LF Wang, FS Wang, X WangMolecular cell 54 (1), 133-146, 2014201
1383
2014
Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation
CL Hsieh, T Fei, Y Chen, T Li, Y Gao, X Wang, T Sun, CJ Sweeney, ...Proceedings of the National Academy of Sciences 111 (20), 7319-7324, 2014201
370
2014
Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer
Z Du, T Sun, E Hacisuleyman, T Fei, X Wang, M Brown, JL Rinn, MGS Lee, ...Nature communications 7 (1), 10982, 2016201
281
2016
A plug release mechanism for membrane permeation by MLKL
L Su, B Quade, H Wang, L Sun, X Wang, J RizoStructure 22 (10), 1489-1500, 2014201
209
2014
Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis
X Jiang, H Jiang, Z Shen, X WangProceedings of the National Academy of Sciences 111 (41), 14782-14787, 4
201
2014
A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis
D Li, T Xu, Y Cao, H Wang, L Li, S Chen, X Wang, Z ShenProceedings of the National Academy of Sciences 112 (16), 5017-5022, 2015201
144
2015
RIP kinases as modulators of inflammation and immunity
S He, X WangNature immunology 19 (9), 912-922, 2018201
143
2018
Small-molecule activation of the TRAIL receptor DR5 in human cancer cells
G Wang, X Wang, H Yu, S Wei, N Williams, DL Holmes, R Halfmann, ...Nature chemical biology 9 (2), 84-89, 2013201
109
2013
RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality
L Meng, W Jin, X WangProceedings of the National Academy of Sciences 112 (35), 11007-11012, 2015201
107
2015
Surface modification of recycled carbon fiber and its reinforcement effect on nylon 6 composites: Mechanical properties, morphology and crystallization behaviors
N Feng, X Wang, D WuCurrent Applied Physics 13 (9), 2038-2050, 2013201
93
2013
Natural product kongensin A is a non-canonical HSP90 inhibitor that blocks RIP3-dependent necroptosis
D Li, C Li, L Li, S Chen, L Wang, Q Li, X Wang, X Lei, Z ShenCell chemical biology 23 (2), 257-266, 2016201
88
2016
Discovery of a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) for the treatment of systemic inflammatory response syndrome
Y Ren, Y Su, L Sun, S He, L Meng, D Liao, X Liu, Y Ma, C Liu, S Li, ...Journal of medicinal chemistry 60 (3), 972-986, 2017201
82
2017
Probing gender-specific lipid metabolites and diagnostic biomarkers for lung cancer using Fourier transform ion cyclotron resonance mass spectrometry
Y Guo, X Wang, L Qiu, X Qin, H Liu, Y Wang, F Li, X Wang, G Chen, ...Clinica chimica acta 414, 135-141, 2012201
75
2012
RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system
D Li, L Meng, T Xu, Y Su, X Liu, Z Zhang, X Wangelife 6, e27692, 2017201
68
2017
Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein
B Yan, L Liu, S Huang, Y Ren, H Wang, Z Yao, L Li, S Chen, X Wang, ...Chemical Communications 53 (26), 37-3640, 2017201
63
2017
A small molecule that protects the integrity of the electron transfer chain blocks the mitochondrial apoptotic pathway
X Jiang, L Li, Z Ying, C Pan, S Huang, L Li, M Dai, B Yan, M Li, H Jiang, ...Molecular cell 63 (2), 229-239, 2016201
58
2016
Human heat shock protein 105/110 kDa (Hsp105/110) regulates biogenesis and quality control of misfolded cystic fibrosis transmembrane conductance regulator at multiple levels
A Saxena, YK Banasavadi-Siddegowda, Y Fan, S Bhattacharya, G Roy, ...Journal of Biological Chemistry 287 (23), 19158-19170, 2012201
57
2012
Synthesis and performance of cyclomatrix polyphosphazene derived from trispiro-cyclotriphosphazene as a halogen-free nonflammable material
J Sun, Z Yu, X Wang, D WuACS Sustainable Chemistry & Engineering 2 (2), 231-238, 2014201
57
2014
Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein
D Liao, L Sun, W Liu, S He, X Wang, X LeiMedChemComm 5 (3), 333-337, 2014201
46
2014
Recycled carbon fiber reinforced poly (butylene terephthalate) thermoplastic composites: fabrication, crystallization behaviors and performance evaluation
Y Chen, X Wang, D WuPolymers for advanced technologies 24 (4), 364-375, 2013201
41
2013

Referred From: https://scholar.google.com/citations?user=WXQ7lBQAAAAJ&hl=en

Cited by
Citations 88249
h-index 83
i10-index 130
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