Author

Sivanesan Dakshanamurthy

Professor at Georgetown University Medical Center - Cited by 4,327 - anticancer and antiviral drug discovery and development - Computer aided drug design - Cancer biology - toxicology - drug repurposin

Biography

Sivanesan is a specialist in anti-cancer and anti-infective therapeutics development with an expertise in the inter-disciplinary areas of Science, Medicine, Technology and Business Management. Areas of scientific specialization include Drug Discovery & Development, Computational Chemistry, Medicinal Chemistry, Molecular Biology, Toxicology, Machine Learning/Artificial Intelligence, Software/Algorithm Development, and Bioinformatics. Siva has more than 20 years of experience in the above said areas with 85 plus scientific peer-reviewed publications, and 29 patents.
Title
Cited by
Year
Drug metabolism in preclinical drug development: a survey of the discovery process, toxicology, and computational tools
N T Issa, H Wathieu, A Ojo, S W Byers, S DakshanamurthyCurrent drug metabolism 18 (6), 556-565, 2017201
98
2017
Machine and deep learning approaches for cancer drug repurposing
NT Issa, V Stathias, S Schürer, S DakshanamurthySeminars in cancer biology 68, 132-142, 2021202
95
2021
The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanoma
CM Simbulan-Rosenthal, S Dakshanamurthy, A Gaur, YS Chen, HB Fang, ...Oncotarget 8 (8), 12576, 2017201
45
2017
Cadherin 11 promotes immunosuppression and extracellular matrix deposition to support growth of pancreatic tumors and resistance to gemcitabine in mice
I Peran, S Dakshanamurthy, MD McCoy, A Mavropoulos, B Allo, ...Gastroenterology 160 (4), 19-1372. e13, 2021202
35
2021
Host targeted antiviral (HTA): functional inhibitor compounds of scaffold protein RACK1 inhibit herpes simplex virus proliferation
H Ullah, W Hou, S Dakshanamurthy, Q TangOncotarget 10 (35), 3209, 2019201
30
2019
Methods and systems for populating and searching a drug informatics database
S Dakshanamurthy, OJ PeterUS Patent 11,373,734, 2022202
17
2022
The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
C Shen, A Nayak, LR Neitzel, AA Adams, M Silver-Isenstadt, LM Sawyer, ...Nature communications 12 (1), 5263, 2021202
17
2021
Single-cell and bulk RNASeq profiling of COVID-19 patients reveal immune and inflammatory mechanisms of infection-induced organ damage
A Bass, Y Liu, S DakshanamurthyViruses 13 (12), 2418, 2021202
15
2021
Immune characterization and profiles of SARS-CoV-2 infected patients reveals potential host therapeutic targets and SARS-CoV-2 oncogenesis mechanism
M Policard, S Jain, S Rego, S DakshanamurthyVirus Research 301, 198464, 2021202
12
2021
Differential prioritization of therapies to subtypes of triple negative breast cancer using a systems medicine method
H Wathieu, NT Issa, AI Fernandez, M Mohandoss, DM Tiek, JL Franke, ...Oncotarget 8 (54), 226, 2017201
9
2017
Design of Peptide Vaccine for COVID19: CD8+ and CD4+ T cell epitopes from SARS-CoV-2 open-reading-frame protein variants
S Parn, G Jabbour, V Nguyenkhoa, S DakshanamurthyBioRxiv, 2021.09. 21.461301, 2021202
7
2021
Predicting new drug indications for prostate cancer: The integration of an in silico proteochemometric network pharmacology platform with patient‐derived primary prostate cells
A Naeem, S Dakshanamurthy, H Walthieu, E Parasido, M Avantaggiati, ...The Prostate 80 (14), 1233-1243, 2020202
7
2020
Design of t cell epitope-based vaccine candidate for SARS-CoV-2 targeting nucleocapsid and spike protein escape variants
G Jabbour, S Rego, V Nguyenkhoa, S DakshanamurthyBioRxiv, 2021.09. 11.49907, 2021202
5
2021
Predicting chemical carcinogens using a hybrid neural network deep learning method
S Limbu, S DakshanamurthySensors 22 (21), 818, 2022202
5
2022
A new epitope selection method: application to design a multi-valent epitope vaccine targeting hras oncogene in squamous cell carcinoma
K Savsani, G Jabbour, S DakshanamurthyVaccines 10 (1), 63, 2021202
4
2021
Small compounds targeting tyrosine phosphorylation of Scaffold Protein Receptor for Activated C Kinase1A (RACK1A) regulate auxin mediated lateral root development in Arabidopsis
SO Alshammari, S Dakshanamurthy, H UllahPlant Signaling & Behavior 16 (5), 189988, 2021202
4
2021
Proglumide reverses nonalcoholic steatohepatitis by interaction with the Farnesoid X receptor and altering the microbiome
MD Gay, H Cao, N Shivapurkar, S Dakshanamurthy, B Kallakury, ...International Journal of Molecular Sciences 2 (), 1899, 2022202
3
2022
Predicting environmental chemical carcinogenicity using a hybrid machine-learning approach
S Limbu, S DakshanamurthybioRxiv, 2021.05. 0.442477, 2021202
3
2021
Prediction of chemical multi-target profiles and adverse outcomes with systems toxicology
H Wathieu, A Ojo, S DakshanamurthyCurrent Medicinal Chemistry 24 (16), 1705-1720, 2017201
3
2017
A novel chemo-phenotypic method identifies mixtures of salpn, vitamin D3, and pesticides involved in the development of colorectal and pancreatic cancer
NT Issa, H Wathieu, E Glasgow, I Peran, E Parasido, T Li, ...Ecotoxicology and environmental safety 33, 113330, 0
2
2022

Referred From: https://scholar.google.com/citations?user=oW57E1QAAAAJ&hl=en

Cited by
Citations 4327
h-index 34
i10-index 68
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