Author

Alexander J Prokopienko

Postdoctoral Fellow, University of Pittsburgh - Cited by 257 - Kidney disease - clinical pharmacology - human microbiome

Biography

Experienced in clinical pharmacology and clinical development in academia and industry. Matrix leadership experience leading the design and conduct of clinical FIH, ADME, DDI, OC-DDI studies. Pediatric development experience with regulatory interaction, study design and conduct. Experience contributing to the design and analysis of phase 2 and 3 studies. Also, experienced with representing Clin Pharm in regulatory interactions. Thesis covered bench to bedside experiments evaluating the gut microbiome and drug metabolism in kidney disease
Title
Cited by
Year
Trimethylamine N-oxide and cardiovascular outcomes in patients with ESKD receiving maintenance hemodialysis
JR Stubbs, MR Stedman, S Liu, J Long, Y Franchetti, RE West III, ...Clinical journal of the American Society of Nephrology: CJASN 14 (2), 261, 2019201
53
2019
Microbiota-derived uremic retention solutes: perpetrators of altered nonrenal drug clearance in kidney disease
AJ Prokopienko, TD NolinExpert review of clinical pharmacology 11 (1), 71-82, 2018201
32
2018
Decreased kidney function is associated with enhanced hepatic flavin monooxygenase activity and increased circulating trimethylamine N-oxide concentrations in mice
C Johnson, AJ Prokopienko, RE West, TD Nolin, JR StubbsDrug Metabolism and Disposition 46 (9), 1304-1309, 2018201
31
2018
Peer Reviewed: NSAID-Avoidance Education in Community Pharmacies for Patients at High Risk for Acute Kidney Injury, Upstate New York, 2011
SM Jang, J Cerulli, DW Grabe, C Fox, JA Vassalotti, AJ Prokopienko, ...Preventing chronic disease 11, 2014201
30
2014
Development and validation of a UHPLC-MS/MS method for measurement of a gut-derived uremic toxin panel in human serum: an application in patients with kidney disease
AJ Prokopienko, RE West III, JR Stubbs, TD NolinJournal of pharmaceutical and biomedical analysis 174, 618-624, 2019201
27
2019
Lipoteichoic acid from Staphylococcus aureus induces lung endothelial cell barrier dysfunction: role of reactive oxygen and nitrogen species
AB Pai, H Patel, AJ Prokopienko, H Alsaffar, N Gertzberg, P Neumann, ...PloS one 7 (11), e49209, 2012201
27
2012
Restoring glucose uptake rescues neutrophil dysfunction and protects against systemic fungal infection in mouse models of kidney disease
CV Jawale, K Ramani, D Li, BM Coleman, RS Oberoi, S Kupul, L Lin, ...Science translational medicine 12 (548), eaay5691, 2020202
19
2020
Endotoxin binding by sevelamer: potential impact on nutritional status
N Kubotera, AJ Prokopienko, AO Garba, AB PaiInternational journal of nephrology 2013, 2013201
15
2013
Metabolic Activation of Flavin Monooxygenase-mediated Trimethylamine-N-Oxide Formation in Experimental Kidney Disease
AJ Prokopienko, RE West III, DP Schrum, JR Stubbs, FA Leblond, ...Scientific Reports 9 (1), 15901, 2019201
11
2019
Randomized, placebo-controlled trial of rifaximin therapy for lowering gut-derived cardiovascular toxins and inflammation in CKD
C Kimber, S Zhang, C Johnson, RE West III, AJ Prokopienko, JD Mahnken, ...Kidney360 1 (11), 1206, 2020202
9
2020
Restoring glucose uptake rescues neutrophil dysfunction and protects against fatal bloodstream fungal infections in kidney disease
CV Jawale, K Ramani, D Li, BM Coleman, RS Oberoi, S Kupul, L Lin, ...Science translational medicine 2 (548), 2020202
1
2020
MECHANISTIC EVALUATION OF INCREASED FLAVIN-CONTAINING MONOOXYGENASE FORMATION OF THE GUT-DERIVED CARDIOVASCULAR DISEASE RISK FACTOR TRIMETHYLAMINE-N-OXIDE IN EXPERIMENTAL …
AJ Prokopienko, RE West III, JR Stubbs, R Venkataramanan, V Pichette, ...CLINICAL PHARMACOLOGY & THERAPEUTICS 05, S68-S69, 20920
1
2019
Quantification of lipoteichoic acid in hemodialysis patients with central venous catheters
A Barton Pai, A Garba, P Neumann, AJ Prokopienko, G Costello, ...Frontiers in Medicine 5, 308, 20820
1
2018

Referred From: https://scholar.google.com/citations?user=SMMoDDYAAAAJ&hl=en

Cited by
Citations 257
h-index 9
i10-index 9
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