Author

Alexander Statsyuk

University of Houston - Cited by 1,238 - Chemical Biology - Ubiquitin - Pharmacology - Basic Research

Biography

Alexander Statsyuk is an assistant professor at the University of Houston College of Pharmacy. He obtained his Ph.D. degree at the University of Chicago in 2006, where he synthesized natural product Bistramide A and established its mode of action in cells. He then completed his postdoctoral work at UCSF, where he was working on the development of chemical cross-linkers to identify upstream kinases of protein phosphorylation sites. Since 2010 he has been running his independent research program aimed at discovering drug leads targeting degradation pathways such as ubiquitin proteasome system and autophagy. 
Title
Cited by
Year
A fragment-based method to discover irreversible covalent inhibitors of cysteine proteases
SG Kathman, Z Xu, AV StatsyukJournal of medicinal chemistry 57 (11), 4969-4974, 2014201
169
2014
Synthesis of Bistramide A
AV Statsuk, D Liu, SA KozminJournal of the American Chemical Society 126 (31), 9546-9547, 2004200
141
2004
Actin is the primary cellular receptor of bistramide A
AV Statsuk, R Bai, JL Baryza, VA Verma, E Hamel, PA Wender, ...Nature Chemical Biology 1 (7), 383-8, 2005200
97
2005
A small molecule that switches a ubiquitin ligase from a processive to a distributive enzymatic mechanism
SG Kathman, I Span, AT Smith, Z Xu, J Zhan, AC Rosenzweig, ...Journal of the American Chemical Society 137 (39), 12442-12445, 2015201
93
2015
Tuning a three-component reaction for trapping kinase substrate complexes
AV Statsuk, DJ Maly, MA Seeliger, MA Fabian, WH Biggs, DJ Lockhart, ...Journal of the American Chemical Society 130 (51), 17568-74, 2008200
81
2008
Covalent tethering of fragments for covalent probe discovery
SG Kathman, AV StatsyukMedChemComm 7 (4), 576-585, 2016201
77
2016
Reaction of 2-Methylene-1,3-dicarbonyl Compounds Containing a CF3-Group with 1,3-Dienes
VG Nenajdenko, AV Statsuk, ES BalenkovaTetrahedron 56 (35), 6549-6556, 2000200
76
2000
An inhibitor of ubiquitin conjugation and aggresome formation
H An, AV StatsyukChemical science 6 (9), 5235-5245, 2015201
50
2015
Development of activity-based probes for ubiquitin and ubiquitin-like protein signaling pathways
H An, AV StatsyukJournal of the American Chemical Society 135 (45), 16948-16962, 2013201
50
2013
Crosstalk between kinases and Nedd4 family ubiquitin ligases
H An, DT Krist, AV StatsyukMolecular bioSystems 10 (7), 1643-1657, 2014201
40
2014
Dissecting the specificity of adenosyl sulfamate inhibitors targeting the ubiquitin-activating enzyme
M Misra, M Kuhn, M Löbel, H An, AV Statsyuk, C Sotriffer, H SchindelinStructure 25 (7), 1120-1129. e3, 2017201
37
2017
Covalent-fragment screening of BRD4 identifies a ligandable site orthogonal to the acetyl-lysine binding sites
MD Olp, DJ Sprague, CJ Goetz, SG Kathman, SL Wynia-Smith, ...ACS chemical biology 15 (4), 1036-1049, 2020202
34
2020
Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies
K Juenemann, AHP Jansen, L van Riel, R Merkx, MPC Mulder, H An, ...Scientific Reports 8 (1), 1405, 2018201
33
2018
Protein ubiquitination and formation of polyubiquitin chains without ATP, E1 and E2 enzymes
S Park, DT Krist, AV StatsyukChemical Science 6 (3), 1770-1779, 2015201
28
2015
UbMES and UbFluor: novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN
S Park, PK Foote, DT Krist, SE Rice, AV StatsyukJournal of Biological Chemistry 292 (40), 16539-16553, 2017201
26
2017
UbFluor: a mechanism-based probe for HECT E3 ligases
DT Krist, S Park, GH Boneh, SE Rice, AV StatsyukChemical science 7 (8), 5587-5595, 2016201
25
2016
Facile synthesis of covalent probes to capture enzymatic intermediates during E1 enzyme catalysis
H An, AV StatsyukChemical Communications 52 (12), 77-80, 2016201
24
2016
Discovery of covalent enzyme inhibitors using virtual docking of covalent fragments
SR Chowdhury, S Kennedy, K Zhu, R Mishra, P Chuong, A Nguyen, ...Bioorganic & medicinal chemistry letters 29 (1), 36-39, 2019201
22
2019
Mapping low-affinity/high-specificity peptide–protein interactions using ligand-footprinting mass spectrometry
BW Parker, EJ Goncz, DT Krist, AV Statsyuk, AI Nesvizhskii, EL WeissProceedings of the National Academy of Sciences 116 (42), 21001-21011, 2019201
18
2019
Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain
D McShan, S Kathman, B Lowe, Z Xu, J Zhan, A Statsyuk, IV OgungbeBioorganic & medicinal chemistry letters 25 (20), 4509-4512, 2015201
18
2015

Referred From: https://scholar.google.com/citations?user=fVWsHecAAAAJ&hl=en

Cited by
Citations 1238
h-index 18
i10-index 25
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