Author

Khaled Barakat

University of Alberta - Cited by 2,780

Biography

Dr. Barakat received his Ph.D. in biophysics from the University of Alberta in 2012 followed by a postdoctoral fellowship in the lab of the Nobel Laureate, Professor Michael Houghton, for two years. During his career, Dr. Barakat received numerous awards including the CIHR and AIHS postdoctoral fellowships, the prestigious UofA dissertation award, the ACRI Studentship and many distinguished awards throughout his undergraduate and graduate studies. Dr. Barakat is also the editor of a number of journals. 
Title
Cited by
Year
Comprehensive in vitro characterization of PD-L1 small molecule inhibitors
A Ganesan, M Ahmed, I Okoye, E Arutyunova, D Babu, WL Turnbull, ...Scientific reports 9 (1), 12392, 2019201
98
2019
Development of safe drugs: the hERG challenge
S Kalyaanamoorthy, KH BarakatMedicinal research reviews 38 (2), 525-555, 2018201
86
2018
Cardiac late sodium channel current is a molecular target for the sodium/glucose cotransporter 2 inhibitor empagliflozin
K Philippaert, S Kalyaanamoorthy, M Fatehi, W Long, S Soni, NJ Byrne, ...Circulation 143 (22), 2188-2204, 2021202
84
2021
Targeting B7‐1 in immunotherapy
R Chen, A Ganesan, I Okoye, E Arutyunova, S Elahi, MJ Lemieux, ...Medicinal Research Reviews 40 (2), 654-682, 2020202
37
2020
Revealing the atomistic details behind the binding of B7–1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study
A Ganesan, TC Moon, KH BarakatBiochimica et Biophysica Acta (BBA)-General Subjects 1862 (12), 2764-2778, 2018201
31
2018
Computer-aided drug design
PV BharatamDrug Discovery and Development: From Targets and Molecules to Medicines, 137-210, 2021202
29
2021
L-type calcium channels: structure and functions
T Feng, S Kalyaanamoorthy, K BarakatIon Channels in Health and Sickness 77305, 2018201
27
2018
Design, synthesis, biological evaluation and dynamics simulation of indazole derivatives with antiangiogenic and antiproliferative anticancer activity
NMY Elsayed, RAT Serya, MF Tolba, M Ahmed, K Barakat, ...Bioorganic Chemistry 82, 340-359, 2019201
23
2019
Binding modes of hERG blockers: an unsolved mystery in the drug design arena
S Kalyaanamoorthy, KH BarakatExpert Opinion on Drug Discovery 13 (3), 207-210, 2018201
23
2018
Effects of protein-protein interactions and ligand binding on the ion permeation in KCNQ1 potassium channel
H Jalily Hasani, A Ganesan, M Ahmed, KH BarakatPLoS One 13 (2), e0191905, 2018201
21
2018
Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor
J Groenendyk, T Paskevicius, H Urra, C Viricel, K Wang, K Barakat, ...Scientific reports 8 (1), 16678, 181
20
2018
Computer‐aided drug design of small molecule inhibitors of the ERCC1‐XPF protein–protein interaction
F Gentile, AH Elmenoufy, G Ciniero, D Jay, F Karimi‐Busheri, KH Barakat, ...Chemical Biology & Drug Design 95 (4), 460-471, 2020202
18
2020
Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations
Y Tabana, TC Moon, A Siraki, S Elahi, K BarakatExpert Opinion on Therapeutic Targets 25 (5), 347-363, 2021202
16
2021
Atomistic modeling and molecular dynamics analysis of human CaV1. 2 channel using external electric field and ion pulling simulations
T Feng, S Kalyaanamoorthy, A Ganesan, K BarakatBiochimica et Biophysica Acta (BBA)-General Subjects 1863 (6), 1116-1126, 2019201
15
2019
A structure-based computational workflow to predict liability and binding modes of small molecules to hERG
S Kalyaanamoorthy, SM Lamothe, X Hou, TC Moon, HT Kurata, ...Scientific reports 10 (1), 16262, 2020202
15
2020
Targeting DNA repair in tumor cells via inhibition of ERCC1–XPF
AH Elmenoufy, F Gentile, D Jay, F Karimi-Busheri, X Yang, OM Soueidan, ...Journal of Medicinal Chemistry 62 (17), 7684-7696, 2019201
15
2019
Antibodies to cryptic epitopes in distant homologues underpin a mechanism of heterologous immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA
CJ Mitran, A Mena, S Gnidehou, S Banman, E Arango, BAS Lima, H Lugo, ...MBio 10 (5), 10.1128/mbio. 02343-19, 2019201
14
2019
Molecular Dynamics Simulation and the Prediction of Druggable Binding Sites
T Feng, K BarakatComputational Drug Discovery and Design 1762, 2018201
13
2018
A ‘deep dive’into the SARS-Cov-2 polymerase assembly: identifying novel allosteric sites and analyzing the hydrogen bond networks and correlated dynamics
K Barakat, M Ahmed, Y Tabana, M HaJournal of Biomolecular Structure and Dynamics 40 (19), 9443-9463, 2022202
12
2022
GRP78: A possible relationship of COVID-19 and the mucormycosis; in silico perspective
AM Elgohary, AA Elfiky, K BarakatComputers in biology and medicine 139, 104956, 2021202
12
2021

Referred From: https://scholar.google.com/citations?user=j-f21_sAAAAJ&hl=en

Cited by
Citations 2780
h-index 30
i10-index 62
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