Author

Barakat K

University of Alberta - Cited by 2,780

Biography

Dr. Barakat is the leader of a multidisciplinary world-class research team to develop novel immunotherapy drugs targeting the immune checkpoints' proteins. He received his PhD in biophysics from the University of Alberta in 2012 followed by a postdoctoral fellowship in Professor Michael Houghton’s Lab for two years
Title
Cited by
Year
Comprehensive in vitro characterization of PD-L1 small molecule inhibitors
A Ganesan, M Ahmed, I Okoye, E Arutyunova, D Babu, WL Turnbull, ...Scientific reports 9 (1), 12392, 2019201
98
2019
Development of safe drugs: the hERG challenge
S Kalyaanamoorthy, KH BarakatMedicinal research reviews 38 (2), 525-555, 2018201
86
2018
Cardiac late sodium channel current is a molecular target for the sodium/glucose cotransporter 2 inhibitor empagliflozin
K Philippaert, S Kalyaanamoorthy, M Fatehi, W Long, S Soni, NJ Byrne, ...Circulation 143 (22), 2188-2204, 2021202
84
2021
Targeting B7‐1 in immunotherapy
R Chen, A Ganesan, I Okoye, E Arutyunova, S Elahi, MJ Lemieux, ...Medicinal Research Reviews 40 (2), 654-682, 2020202
37
2020
Revealing the atomistic details behind the binding of B7–1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study
A Ganesan, TC Moon, KH BarakatBiochimica et Biophysica Acta (BBA)-General Subjects 1862 (12), 2764-2778, 2018201
31
2018
Computer-aided drug design
PV BharatamDrug Discovery and Development: From Targets and Molecules to Medicines, 137-210, 2021202
29
2021
L-type calcium channels: structure and functions
T Feng, S Kalyaanamoorthy, K BarakatIon Channels in Health and Sickness 77305, 2018201
27
2018
Binding modes of hERG blockers: an unsolved mystery in the drug design arena
S Kalyaanamoorthy, KH BarakatExpert Opinion on Drug Discovery 13 (3), 207-210, 2018201
23
2018
Design, synthesis, biological evaluation and dynamics simulation of indazole derivatives with antiangiogenic and antiproliferative anticancer activity
NMY Elsayed, RAT Serya, MF Tolba, M Ahmed, K Barakat, ...Bioorganic Chemistry 82, 340-359, 2019201
23
2019
Effects of protein-protein interactions and ligand binding on the ion permeation in KCNQ1 potassium channel
H Jalily Hasani, A Ganesan, M Ahmed, KH BarakatPLoS One 13 (2), e0191905, 2018201
21
2018
Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor
J Groenendyk, T Paskevicius, H Urra, C Viricel, K Wang, K Barakat, ...Scientific reports 8 (1), 16678, 181
20
2018
Computer‐aided drug design of small molecule inhibitors of the ERCC1‐XPF protein–protein interaction
F Gentile, AH Elmenoufy, G Ciniero, D Jay, F Karimi‐Busheri, KH Barakat, ...Chemical Biology & Drug Design 95 (4), 460-471, 2020202
18
2020
Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations
Y Tabana, TC Moon, A Siraki, S Elahi, K BarakatExpert Opinion on Therapeutic Targets 25 (5), 347-363, 2021202
16
2021
A structure-based computational workflow to predict liability and binding modes of small molecules to hERG
S Kalyaanamoorthy, SM Lamothe, X Hou, TC Moon, HT Kurata, ...Scientific reports 10 (1), 16262, 2020202
15
2020
Targeting DNA repair in tumor cells via inhibition of ERCC1–XPF
AH Elmenoufy, F Gentile, D Jay, F Karimi-Busheri, X Yang, OM Soueidan, ...Journal of Medicinal Chemistry 62 (17), 7684-7696, 2019201
15
2019
Atomistic modeling and molecular dynamics analysis of human CaV1. 2 channel using external electric field and ion pulling simulations
T Feng, S Kalyaanamoorthy, A Ganesan, K BarakatBiochimica et Biophysica Acta (BBA)-General Subjects 1863 (6), 1116-1126, 2019201
15
2019
Antibodies to cryptic epitopes in distant homologues underpin a mechanism of heterologous immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA
CJ Mitran, A Mena, S Gnidehou, S Banman, E Arango, BAS Lima, H Lugo, ...MBio 10 (5), 10.1128/mbio. 02343-19, 2019201
14
2019
Molecular Dynamics Simulation and the Prediction of Druggable Binding Sites
T Feng, K BarakatComputational Drug Discovery and Design 1762, 2018201
13
2018
A ‘deep dive’into the SARS-Cov-2 polymerase assembly: identifying novel allosteric sites and analyzing the hydrogen bond networks and correlated dynamics
K Barakat, M Ahmed, Y Tabana, M HaJournal of Biomolecular Structure and Dynamics 40 (19), 9443-9463, 2022202
12
2022
GRP78: A possible relationship of COVID-19 and the mucormycosis; in silico perspective
AM Elgohary, AA Elfiky, K BarakatComputers in biology and medicine 139, 104956, 2021202
12
2021

Referred From: https://scholar.google.com/citations?user=j-f21_sAAAAJ&hl=en&oi=ao

Cited by
Citations 2780
h-index 30
i10-index 62
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