Author

Hong- Gang Wang

Professor of Pediatrics, Penn State College of Medicine - Cited by 46,311 - Cancer Biology

Biography

Dr. Hong-Gang “H.G.” Wang formerly worked at the H. Lee Moffitt Cancer Center and the University of South Florida in Tampa, beginning as assistant professor in 1998 and advancing to the rank of professor before moving to Penn State College of Medicine in 2008. Research in Dr. Wang’s laboratory aims to better understand the fundamental mechanisms that control apoptosis (self-killing) and autophagy (self-eating) in the context of oncogenesis. In addition, targeting of these two closely related but distinct self-destructive cellular processes for anticancer drug discovery and development is another major interest of his research group.
Title
Cited by
Year
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...autophagy 17 (1), 1-382, 202112436202
12436
2021
An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure
Y Takahashi, H He, Z Tang, T Hattori, Y Liu, MM Young, JM Serfass, ...Nature communications 9 (1), 2855, 2018201
245
2018
Mechanisms and context underlying the role of autophagy in cancer metastasis
CM Dower, CA Wills, SM Frisch, HG WangAutophagy 14 (7), 1110-1128, 2018201
163
2018
TOM40 targets Atg2 to mitochondria-associated ER membranes for phagophore expansion
Z Tang, Y Takahashi, H He, T Hattori, C Chen, X Liang, H Chen, ...Cell reports 28 (7), 1744-1757. e5, 2019201
81
2019
VPS37A directs ESCRT recruitment for phagophore closure
Y Takahashi, X Liang, T Hattori, Z Tang, H He, H Chen, X Liu, T Abraham, ...Journal of Cell Biology 218 (10), 3336-3354, 2019201
74
2019
Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis
Z Tang, Y Takahashi, C Chen, Y Liu, H He, N Tsotakos, JM Serfass, ...Cell Death & Differentiation 24 (12), 2127-2138, 2017201
72
2017
Targeted inhibition of ULK1 promotes apoptosis and suppresses tumor growth and metastasis in neuroblastoma
CM Dower, N Bhat, MT Gebru, L Chen, CA Wills, BA Miller, HG WangMolecular cancer therapeutics 17 (11), 2365-2376, 2018201
63
2018
Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ
Z Liu, Y Wei, L Zhang, PP Yee, M Johnson, X Zhang, M Gulley, ...Oncogene 38 (1), 120-139, 2019201
57
2019
Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells
KE Clements, T Thakar, CM Nicolae, X Liang, HG Wang, GL MoldovanNucleic acids research 46 (17), 8898-8907, 2018201
50
2018
TP53 is required for BECN1-and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition
S Lima, K Takabe, J Newton, K Saurabh, MM Young, AM Leopoldino, ...Autophagy 14 (6), 942-957, 2018201
45
2018
A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission
TG Flower, Y Takahashi, A Hudait, K Rose, N Tjahjono, AJ Pak, ...Nature structural & molecular biology 27 (6), 570-580, 2020202
42
2020
Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens
KE Clements, EM Schleicher, T Thakar, A Hale, A Dhoonmoon, ...Nature communications 11 (1), 6118, 2020202
35
2020
Therapeutic targeting of FLT3 and associated drug resistance in acute myeloid leukemia
MT Gebru, HG WangJournal of Hematology & Oncology 13, 1-13, 2020202
34
2020
Sphingolipids as regulators of autophagy and endocytic trafficking
MM Young, HG WangAdvances in Cancer Research 140, 27-60, 2018201
33
2018
Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation
SF Tan, W Dunton, X Liu, TE Fox, SAF Morad, D Desai, K Doi, ...Journal of lipid research 60 (6), 1078-1086, 2019201
31
2019
Selective reversible inhibition of autophagy in hypoxic breast cancer cells promotes pulmonary metastasis
CM Dower, N Bhat, EW Wang, HG WangCancer research 77 (3), 646-657, 2017201
30
2017
Chemotherapy-induced upregulation of small extracellular vesicle-associated PTX3 accelerates breast cancer metastasis
CA Wills, X Liu, L Chen, Y Zhao, CM Dower, J Sundstrom, HG WangCancer research 81 (2), 452-463, 2021202
29
2021
Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia
BM Barth, W Wang, PT Toran, TE Fox, C Annageldiyev, RM Ondrasik, ...Blood advances 3 (17), 2598-2603, 2019201
28
2019
SKI-178: a multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models
JA Hengst, TE Dick, A Sharma, K Doi, S Hegde, SF Tan, LM Geffert, ...Cancer translational medicine 3 (4), 109, 2017201
26
2017
Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection
JM Serfass, Y Takahashi, Z Zhou, YI Kawasawa, Y Liu, N Tsotakos, ...Journal of Biological Chemistry 292 (24), 10097-10111, 2017201
25
2017

Referred From: https://scholar.google.com/citations?user=kuvhxRwAAAAJ&hl=en

Cited by
Citations 46311
h-index 77
i10-index 166
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