Author

Afshin Samali

Professor of Cancer Biology, Apoptosis Research Centre; University of Galway - Cited by 40,267 - Apoptosis - Cancer - cell death - endoplasmic reticulum - ER stress

Biography

Professor Samali is a leading cancer biologist with expertise in the field of endoplasmic reticulum (ER) stress and cell death/survival signaling in cancer, with a successful research career spanning over 30 years.
Title
Cited by
Year
Endoplasmic reticulum stress signalling–from basic mechanisms to clinical applications
A Almanza, A Carlesso, C Chintha, S Creedican, D Doultsinos, B Leuzzi, ...The FEBS journal 286 (2), 241-278, 2019201
565
2019
Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response
S Hombach-Klonisch, M Mehrpour, S Shojaei, C Harlos, M Pitz, A Hamai, ...Pharmacology & therapeutics 184, 13-41, 2018201
236
2018
The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance
E Madden, SE Logue, SJ Healy, S Manie, A SamaliBiology of the Cell 111 (1), 1-17, 2019201
214
2019
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy
SE Logue, EP McGrath, P Cleary, S Greene, K Mnich, A Almanza, ...Nature communications 9 (1), 3267, 2018201
195
2018
Dual IRE 1 RN ase functions dictate glioblastoma development
S Lhomond, T Avril, N Dejeans, K Voutetakis, D Doultsinos, M McMahon, ...EMBO molecular medicine 10 (3), e7929, 2018201
133
2018
Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts
S Ghavami, B Yeganeh, AA Zeki, S Shojaei, NJ Kenyon, S Ott, A Samali, ...American Journal of Physiology-Lung Cellular and Molecular Physiology 314 (3 …, 2018201
110
2018
Tumour cell secretome in chemoresistance and tumour recurrence
EC Madden, AM Gorman, SE Logue, A SamaliTrends in cancer 6 (6), 489-505, 2020202
98
2020
Regulation of lipid metabolism by the unfolded protein response
M Moncan, K Mnich, A Blomme, A Almanza, A Samali, AM GormanJournal of cellular and molecular medicine 25 (3), 1359-1370, 2021202
69
2021
The unfolded protein response in breast cancer
EP McGrath, SE Logue, K Mnich, S Deegan, R Jäger, AM Gorman, ...Cancers 10 (10), 344, 2018201
65
2018
The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors
M Mahameed, T Wilhelm, O Darawshi, A Obiedat, WS Tommy, C Chintha, ...Cell death & disease 10 (4), 300, 2019201
65
2019
Control of anterior GR adient 2 (AGR 2) dimerization links endoplasmic reticulum proteostasis to inflammation
M Maurel, J Obacz, T Avril, YP Ding, O Papadodima, X Treton, F Daniel, ...EMBO molecular medicine 11 (6), e10120, 2019201
48
2019
Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases
JC Duvigneau, A Luís, AM Gorman, A Samali, D Kaltenecker, R Moriggl, ...Cytokine 124, 154577, 2019201
46
2019
Simvastatin induces unfolded protein response and enhances temozolomide-induced cell death in glioblastoma cells
S Dastghaib, S Shojaei, Z Mostafavi-Pour, P Sharma, JB Patterson, ...Cells 9 (11), 2339, 2020202
36
2020
Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β
A Talty, S Deegan, M Ljujic, K Mnich, SD Naicker, D Quandt, Q Zeng, ...Cell Death & Disease 10 (9), 622, 2019201
35
2019
Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML
E O’Reilly, SPS Dhami, DV Baev, C Ortutay, A Halpin-McCormick, ...Scientific Reports 8 (1), 15752, 2018201
32
2018
ER stress in obesity pathogenesis and management
A Ajoolabady, S Liu, DJ Klionsky, GYH Lip, J Tuomilehto, S Kavalakatt, ...Trends in pharmacological sciences 43 (2), 97-109, 2022202
28
2022
Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo
PJ Le Reste, R Pineau, K Voutetakis, J Samal, G Jegou, S Lhomond, ...Cancer Letters 494, 73-83, 2020202
26
2020
Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors
A Carlesso, C Chintha, AM Gorman, A Samali, LA ErikssonScientific reports 9 (1), 3407, 2019201
26
2019
An emerging role for the unfolded protein response in pancreatic cancer
CM Robinson, A Talty, SE Logue, K Mnich, AM Gorman, A SamaliCancers 13 (2), 261, 2021202
23
2021
Autophagy, apoptosis, the unfolded protein response, and lung function in idiopathic pulmonary fibrosis
P Sharma, J Alizadeh, M Juarez, A Samali, AJ Halayko, NJ Kenyon, ...Cells 10 (7), 1642, 202
21
2021

Referred From: https://scholar.google.com/citations?user=RAMxue0AAAAJ&hl=en

Cited by
Citations 40267
h-index 72
i10-index 155
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