Author

Ann Ager

Professor of Cellular Immunity and Immunotherapy, Cardiff University - Cited by 6,039 - T-cell homing in infectious diseases - cancer and neurodegeneration

Biography

I gained a Ph.D. from Cambridge University studying inflammatory responses in vascular endothelial cells and trained in microvascular endothelial cell biology with Professor Judah Folkman at Harvard Medical School during my post-doctoral studies. In 1983 I moved to the Department of Immunology, the University of Manchester as a postdoctoral fellow working with Professor Bill Ford and started what has become my life-long interest in specialized high endothelial venule (HEV) blood vessels and T-cell homing in health and disease.
Title
Cited by
Year
Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1
MD Crowther, G Dolton, M Legut, ME Caillaud, A Lloyd, M Attaf, ...Nature immunology 21 (2), 178-185, 2020202
198
2020
Tertiary lymphoid structures in cancer: drivers of antitumor immunity, immunosuppression, or bystander sentinels in disease?
EJ Colbeck, A Ager, A Gallimore, GW JonesFrontiers in immunology 8, 1830, 2017201
174
2017
High endothelial venules and other blood vessels: critical regulators of lymphoid organ development and function
A AgerFrontiers in immunology 8, 45, 2017201
153
2017
T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion
JP Hindley, E Jones, K Smart, H Bridgeman, SN Lauder, B Ondondo, ...Cancer research 72 (21), 5473-5482, 2012201
105
2012
Understanding high endothelial venules: lessons for cancer immunology
A Ager, MJ MayOncoimmunology 4 (6), e8791, 2015201
100
2015
Molecular pathology of Lynch syndrome
G Cerretelli, A Ager, MJ Arends, IM FraylingThe Journal of pathology 250 (5), 518-531, 2020202
93
2020
Treg depletion licenses T cell–driven HEV neogenesis and promotes tumor destruction
EJ Colbeck, E Jones, JP Hindley, K Smart, R Schulz, M Browne, S Cutting, ...Cancer immunology research 5 (11), 1005-1015, 2017201
72
2017
High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression
DC Bento, E Jones, S Junaid, J Tull, GT Williams, A Godkin, A Ager, ...Oncoimmunology 4 (3), e974374, 2015201
66
2015
Homing to solid cancers: a vascular checkpoint in adoptive cell therapy using CAR T-cells
A Ager, HA Watson, SC Wehenkel, RN MohammedBiochemical Society Transactions 44 (2), 377-385, 2016201
60
2016
SHP-1: the next checkpoint target for cancer immunotherapy?
HA Watson, S Wehenkel, J Matthews, A AgerBiochemical Society Transactions 44 (2), 356-362, 2016201
59
2016
L-selectin enhanced T cells improve the efficacy of cancer immunotherapy
HA Watson, RRP Durairaj, J Ohme, M Alatsatianos, H Almutairi, ...Frontiers in immunology 10, 1321, 2019201
52
2019
L-selectin is essential for delivery of activated CD8+ T cells to virus-infected organs for protective immunity
RN Mohammed, HA Watson, M Vigar, J Ohme, A Thomson, ...Cell reports 14 (4), 760-771, 2016201
47
2016
Lynch syndrome–cancer pathways, heterogeneity and immune escape
S Seth, A Ager, MJ Arends, IM FraylingThe Journal of pathology 246 (2), 129-133, 2018201
36
2018
Enhancement of T cell responses as a result of synergy between lower doses of radiation and T cell stimulation
LK Spary, S Al-Taei, J Salimu, AD Cook, A Ager, HA Watson, A Clayton, ...The Journal of Immunology 192 (7), 3101-3110, 2014201
33
2014
Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry
JJ Miles, MP Tan, G Dolton, ESJ Edwards, SAE Galloway, B Laugel, ...The Journal of clinical investigation 128 (4), 1569-1580, 2018201
27
2018
Cytokine regulation of lung Th17 response to airway immunization using LPS adjuvant
SM Caucheteux, J Hu-Li, RN Mohammed, A Ager, WE PaulMucosal immunology 10 (2), 361-372, 2017201
22
2017
Defining high endothelial venules and tertiary lymphoid structures in cancer
E Jones, A Gallimore, A AgerTertiary Lymphoid Structures, 99-118, 2018201
21
2018
High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer
PL Pfuderer, A Ballhausen, F Seidler, HJ Stark, N Grabe, IM Frayling, ...British journal of cancer 1 (5), 395-404, 2019201
21
2019
Purity of transferred CD8+ T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP‐1
HA Watson, G Dolton, J Ohme, K Ladell, M Vigar, S Wehenkel, J Hindley, ...Immunology and cell biology 94 (8), 802-808, 202
16
2016
Tetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression
MC Demaria, L Yeung, R Peeters, JL Wee, M Mihaljcic, EL Jones, Z Nasa, ...Iscience 23 (5), 101104, 2020202
14
2020

Referred From: https://scholar.google.co.uk/citations?user=7n2SAkMAAAAJ&hl

Cited by
Citations 6039
h-index 45
i10-index 81
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