Author

WenYong Chen

Associate Professor of Cancer Biology, City of Hope - Cited by 4,341 - Cancer - Aging - Epigenetics

Biography

Dr. Chen is an Associate Professor at the Beckman Research Institute, City of Hope. Dr. Chen received his Ph.D. in Molecular Biology at the University of Alabama at Birmingham in 1999, and completed his postdoctoral training in Cancer Biology with Dr. Stephen B. Baylin at Johns Hopkins University in 2005.
Title
Cited by
Year
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
WY Chen, DH Wang, RWC Yen, J Luo, W Gu, SB BaylinCell 123 (3), 437-448, 2005200
774
2005
Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
L Li, L Wang, L Li, Z Wang, Y Ho, T McDonald, TL Holyoake, WY Chen, ...Cancer cell 21 (2), 266-281, 2012201
426
2012
NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response
B Wang, MK Hasan, E Alvarado, H Yuan, H Wu, WY ChenOncogene 30 (8), 907-921, 2011201
280
2011
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors
WY Chen, X Zeng, MG Carter, CN Morrell, RW Chiu Yen, M Esteller, ...Nature genetics 33 (2), 197-202, 2003200
271
2003
Sorting out functions of sirtuins in cancer
M Roth, WY ChenOncogene 33 (13), 1609-1620, 2014201
267
2014
SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells
L Li, T Osdal, Y Ho, S Chun, T McDonald, P Agarwal, A Lin, S Chu, J Qi, ...Cell stem cell 15 (4), 431-446, 2014201
208
2014
Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis
WY Chen, TK Cooper, CA Zahnow, M Overholtzer, Z Zhao, M Ladanyi, ...Cancer Cell 6 (4), 387-398, 2004200
199
2004
The emerging and diverse roles of sirtuins in cancer: a clinical perspective
H Yuan, L Su, WY ChenOncoTargets and therapy, 1399-1416, 2013201
196
2013
Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
H Yuan, Z Wang, L Li, H Zhang, H Modi, D Horne, R Bhatia, WY ChenBlood, The Journal of the American Society of Hematology 119 (8), 1904-1914, 2012201
183
2012
Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation
WY Chen, TM TownesProceedings of the National Academy of Sciences 97 (1), 377-382, 2000200
153
2000
SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells
Z Wang, H Yuan, M Roth, JM Stark, R Bhatia, WY ChenOncogene 32 (5), 589-598, 2013201
112
2013
Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling
S Nam, A Scuto, F Yang, WY Chen, S Park, HS Yoo, H Konig, R Bhatia, ...Molecular oncology 6 (3), 276-2, 2012201
83
2012
Emerging roles of SIRT1 in cancer drug resistance
Z Wang, WY ChenGenes & cancer 4 (3-4), 82-90, 2013201
81
2013
Lentiviral vector transduction of hematopoietic stem cells that mediate long-term reconstitution of lethally irradiated mice
WY Chen, X Wu, DN Levasseur, H Liu, L Lai, JC Kappes, TM TownesStem Cells 18 (5), 352-359, 2000200
80
2000
Aberrant gene silencing in tumor progression: implications for control of cancer
SB Baylin, WY ChenCold Spring Harbor symposia on quantitative biology 70, 427-433, 2005200
74
2005
An emerging trend of rapid increase of leukemia but not all cancers in the aging population in the United States
T Hao, M Li-Talley, A Buck, WY ChenScientific reports 9 (1), 12070, 2019201
73
2019
BCR-ABL Gene Expression Is Required for Its Mutations in a Novel KCL-22 Cell Culture Model for Acquired Resistance of Chronic Myelogenous Leukemia 2
H Yuan, Z Wang, C Gao, W Chen, Q Huang, JK Yee, R Bhatia, WY ChenJournal of Biological Chemistry 285 (7), 5085-5096, 2010201
70
2010
VISFATIN (NAMPT) improves in vitro IGF1-induced steroidogenesis and IGF1 receptor signaling through SIRT1 in bovine granulosa cells
M Reverchon, C Rame, A Bunel, W Chen, P Froment, J DupontBiology of reproduction 94 (3), 54, 1-13, 2016201
56
2016
Trichostatin A up-regulates human papillomavirus type 11 upstream regulatory region-E6 promoter activity in undifferentiated primary human keratinocytes
W Zhao, F Noya, WY Chen, TM Townes, LT Chow, TR BrokerJournal of virology 73 (6), 5026-5033, 1999199
49
1999
ATRA-induced cellular differentiation and CD38 expression inhibits acquisition of BCR-ABL mutations for CML acquired resistance
Z Wang, Z Liu, X Wu, S Chu, J Wang, H Yuan, M Roth, YC Yuan, R Bhatia, ...PLoS genetics 10 (6), e1004414, 2014201
35
2014

Referred From: https://scholar.google.com/citations?user=kzEgJVEAAAAJ&hl=en&oi=ao

Cited by
Citations 4341
h-index 28
i10-index 30
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