Author

Yong Chen

Shanghai Institute of Biochemistry and Cell Biology - Cited by 5,895 - structural biology - telomere - chromatin remodeling - histone methylation

Biography

Dr. Yong Chen works in the Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China, is a well known researher and one of his famous works are Genetic Engineering of Bacteria that can Produce Urate Oxidase
Title
Cited by
Year
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
KC Wang, YW Yang, B Liu, A Sanyal, R Corces-Zimmerman, Y Chen, ...Nature 472 (7341), 120-124, 2011201
2047
2011
Crystal structure of human histone lysine-specific demethylase 1 (LSD1)
Y Chen, Y Yang, F Wang, K Wan, K Yamane, Y Zhang, M LeiProceedings of the National Academy of Sciences 103 (38), 13956-13961, 2006200
323
2006
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins
Y Chen, Y Yang, M Van Overbeek, JR Donigian, P Baciu, T de Lange, ...Science 319 (5866), 1092-1096, 2008200
302
2008
Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia
F Cao, EC Townsend, H Karatas, J Xu, L Li, S Lee, L Liu, Y Chen, ...Molecular cell 53 (2), 247-261, 2014201
299
2014
Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency
YW Yang, RA Flynn, Y Chen, K Qu, B Wan, KC Wang, M Lei, HY Changelife 3, e02046, 2014201
208
2014
Structural basis for activity regulation of MLL family methyltransferases
Y Li, J Han, Y Zhang, F Cao, Z Liu, S Li, J Wu, C Hu, Y Wang, J Shuai, ...Nature 530 (7591), 447-452, 2016201
208
2016
Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins
J Jiang, X Zhang, Y Chen, Y Wu, ZH Zhou, Z Chang, SF SuiProceedings of the National Academy of Sciences 105 (33), 11939, 2008200
169
2008
High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein–protein interaction
H Karatas, EC Townsend, F Cao, Y Chen, D Bernard, L Liu, M Lei, Y Dou, ...Journal of the American Chemical Society 135 (2), 669-682, 2013201
166
2013
A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms
Y Chen, R Rai, ZR Zhou, J Kanoh, C Ribeyre, Y Yang, H Zheng, P Damay, ...Nature structural & molecular biology 18 (2), 213-221, 2011201
147
2011
TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
R Rai, Y Chen, M Lei, S ChangNature communications 7 (1), 10881, 2016201
134
2016
An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain
F Cao, Y Chen, T Cierpicki, Y Liu, V Basrur, M Lei, Y DouPloS one 5 (11), e14102, 2010201
132
2010
Developmental ROS individualizes organismal stress resistance and lifespan
D Bazopoulou, D Knoefler, Y Zheng, K Ulrich, BJ Oleson, L Xie, M Kim, ...Nature 576 (7786), 301-305, 2019201
132
2019
Structural basis of nucleosome recognition and modification by MLL methyltransferases
H Xue, T Yao, M Cao, G Zhu, Y Li, G Yuan, Y Chen, M Lei, J HuangNature 573 (7774), 445-449, 2019201
126
2019
DnaK and DnaJ facilitated the folding process and reduced inclusion body formation of magnesium transporter CorA overexpressed in Escherichia coli
Y Chen, J Song, S Sui, DN WangProtein expression and purification 32 (2), 221-231, 2003200
120
2003
SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres
B Wan, J Yin, K Horvath, J Sarkar, Y Chen, J Wu, K Wan, J Lu, P Gu, ...Cell reports 4 (5), 861-869, 2013201
118
2013
Practical aspects of overexpressing bacterial secondary membrane transporters for structural studies
DN Wang, M Safferling, MJ Lemieux, H Griffith, Y Chen, XD LiBiochimica et Biophysica Acta (BBA)-Biomembranes 1610 (1), 23-36, 2003200
109
2003
Ring-like pore structures of SecA: Implication for bacterial protein-conducting channels
HW Wang, Y Chen, H Yang, X Chen, MX Duan, PC Tai, SF SuiProceedings of the National Academy of Sciences 100 (7), 4221, 2003200
96
2003
ASH2L regulates ubiquitylation signaling to MLL: trans-regulation of H3 K4 methylation in higher eukaryotes
L Wu, SY Lee, B Zhou, UTT Nguyen, TW Muir, S Tan, Y DouMolecular cell 49 (6), 1108-1120, 2013201
86
2013
Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex
C Hu, R Rai, C Huang, C Broton, J Long, Y Xu, J Xue, M Lei, S Chang, ...Cell research 27 (12), 1485-1502, 2017201
84
2017
Structural basis of ligand recognition and self-activation of orphan GPR52
X Lin, M Li, N Wang, Y Wu, Z Luo, S Guo, GW Han, S Li, Y Yue, X Wei, ...Nature 579 (7797), 152-157, 2020202
81
2020

Referred From: https://scholar.google.com/citations?hl=en&user=SiC1m2kAAAAJ

Cited by
Citations 5895
h-index 29
i10-index 46
Recommended Journals
Open Access Journals