Author

Jessica M. Overstreet

Eli Lilly - Cited by 1,478 - Diabetic Side Complications - Signal Transduction

Biography

Jessica Overstreet is a nephrology trained biologist who uses my expertise to develop novel therapies for Diabetic Kidney Disease at Eli Lilly. She advocate for inclusion at Lilly and within the science community by leading critical initiatives across Lilly Research Laboratories to support a culture that encourages individual authenticity and an environment that supports all to thrive regardless of their dimensions of difference. Her research is funded by the Lilly Innovation Fellowship Award (Eli Lilly) to investigate novel therapeutic targets underlying diabetic kidney disease through an academic-industry partnership.
Title
Cited by
Year
TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities
R Samarakoon, JM Overstreet, PJ HigginsCellular signalling 25 (1), 264-268, 2013201
368
2013
PAI-1: an integrator of cell signaling and migration
RP Czekay, CE Wilkins-Port, SP Higgins, J Freytag, JM Overstreet, ...International journal of cell biology 2011, 2011201
206
2011
TGF-β1→ SMAD/p53/USF2→ PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis
R Samarakoon, JM Overstreet, SP Higgins, PJ HigginsCell and tissue research 347, 117-128, 2012201
164
2012
Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species
R Samarakoon, AD Dobberfuhl, C Cooley, JM Overstreet, S Patel, ...Cellular signalling 25 (11), 2198-2209, 2013201
163
2013
Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity
JM Overstreet, R Samarakoon, KK Meldrum, PJ HigginsCellular signalling 26 (7), 1427-1436, 2014201
92
2014
TGF-β promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration
S Chung, JM Overstreet, Y Li, Y Wang, A Niu, S Wang, X Fan, K Sasaki, ...JCI insight 3 (21), 2018201
80
2018
Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype
S Anorga, JM Overstreet, LL Falke, J Tang, RG Goldschmeding, ...The FASEB Journal 32 (5), 2644, 2018201
69
2018
Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3‐and p53‐dependent fibrotic responses
R Samarakoon, S Helo, AD Dobberfuhl, NS Khakoo, L Falke, ...The Journal of pathology 236 (4), 421-432, 2015201
67
2015
Inhibition of epidermal growth factor receptor activation is associated with improved diabetic nephropathy and insulin resistance in type 2 diabetes
Z Li, Y Li, JM Overstreet, S Chung, A Niu, X Fan, S Wang, Y Wang, ...Diabetes 67 (9), 1847-1857, 2018201
60
2018
Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis
JM Overstreet, Y Wang, X Wang, A Niu, LS Gewin, B Yao, RC Harris, ...The FASEB Journal 31 (10), 4407, 2017201
56
2017
Rac-GTPase promotes fibrotic TGF-β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways
S Patel, J Tang, JM Overstreet, S Anorga, F Lian, A Arnouk, ...The FASEB Journal 33 (9), 9797, 2019201
45
2019
Tumor suppressor ataxia telangiectasia mutated functions downstream of TGF-β1 in orchestrating profibrotic responses
JM Overstreet, R Samarakoon, D Cardona-Grau, R Goldschmeding, ...The FASEB Journal 29 (4), 1258, 2015201
37
2015
Loss of expression of protein phosphatase magnesium-dependent 1A during kidney injury promotes fibrotic maladaptive repair
R Samarakoon, A Rehfuss, NS Khakoo, LL Falke, AD Dobberfuhl, S Helo, ...The FASEB Journal 30 (10), 3308, 2016201
25
2016
Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control
Y Li, S Chung, Z Li, JM Overstreet, L Gagnon, B Grouix, M Leduc, P Laurin, ...JCI insight 3 (10), 2018201
23
2018
Emerging role of tumor suppressor p53 in acute and chronic kidney diseases
JM Overstreet, CC Gifford, J Tang, PJ Higgins, R SamarakoonCellular and Molecular Life Sciences 79 (9), 474, 2022202
13
2022
Pathological and Transcriptome Changes in the ReninAAV db/db uNx Model of Advanced Diabetic Kidney Disease Exhibit Features of Human Disease
SM Harlan, KM Heinz-Taheny, JM Overstreet, MD Breyer, RC Harris, ...Toxicologic pathology 46 (8), 1-8, 2018201
9
2018
Ureteral obstruction-induced renal fibrosis: an in vivo platform for mechanistic discovery and therapeutic intervention
AD Dobberfuhl, R Samarakoon, CE Higgins, BM Mian, JM Overstreet, ...Cell & developmental biology (3), 20220
1
2012

Referred From: https://scholar.google.com/citations?user=6z8LDkcAAAAJ&hl=en

Cited by
Citations 1478
h-index 14
i10-index 15
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