Author

Michael Seimetz

Justus-Liebig University, Excellence Cluster Cardio-Pulmonary System, Dept. of Internal Medicine - Cited by 1,336 - Lung diseases - COPD - pulmonary Hypertension

Biography

Working on pathophysiology, pharmaco-therapeutic interventions and transgenic knock out mouse model approaches to study chronic obstructive pulmonary disease (COPD), associated with pulmonary hypertension (PH). Identification of novel targets and regenerative approaches for the treatment of COPD and PH is the main goal. The major focus is to investigate the role of oxidative and nitrosative stress-associated molecules and lung repair-related proteins focused on molecular biological investigation of NADPH oxidase, NO synthase and FGF-related pathway using cigarette smoke-/elastase-induced emphysema/PH models.
Title
Cited by
Year
Stimulation of soluble guanylate cyclase prevents cigarette smoke–induced pulmonary hypertension and emphysema
N Weissmann, B Lobo, A Pichl, N Parajuli, M Seimetz, R Puig-Pey, ...American journal of respiratory and critical care medicine 189 (11), 1359-1373, 2014201
91
2014
Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells after monocrotaline-induced pulmonary vascular remodeling
F Veit, O Pak, B Egemnazarov, M Roth, D Kosanovic, M Seimetz, ...Antioxidants & redox signaling 19 (18), 2213-2231, 2013201
81
2013
Time course of cigarette smoke-induced changes of systemic inflammation and muscle structure
K Krüger, G Dischereit, M Seimetz, J Wilhelm, N Weissmann, FC MoorenAmerican Journal of Physiology-Lung Cellular and Molecular Physiology 309 (2 …, 2015201
74
2015
Increased cardiovascular disease risk in the HIV-positive population on ART: potential role of HIV-Nef and Tat
T Wang, R Yi, LA Green, S Chelvanambi, M Seimetz, M ClaussCardiovascular Pathology 24 (5), 279-282, 2015201
70
2015
Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2
R Schulz, G Murzabekova, B Egemnazarov, S Kraut, HJ Eisele, ...Journal of hypertension 32 (2), 300-305, 2014201
63
2014
Endurance and resistance training affect high fat diet-induced increase of ceramides, inflammasome expression, and systemic inflammation in mice
C Mardare, K Krüger, G Liebisch, M Seimetz, A Couturier, R Ringseis, ...Journal of diabetes research 2016, 2016201
61
2016
Histological characterization of mast cell chymase in patients with pulmonary hypertension and chronic obstructive pulmonary disease
D Kosanovic, BK Dahal, DM Peters, M Seimetz, M Wygrecka, K Hoffmann, ...Pulmonary circulation 4 (1), 128-136, 2014201
55
2014
Structural and functional prevention of hypoxia-induced pulmonary hypertension by individualized exercise training in mice
N Weissmann, DM Peters, C Klöpping, K Krüger, C Pilat, S Katta, ...American Journal of Physiology-Lung Cellular and Molecular Physiology 306 …, 2014201
43
2014
Increased S100A4 expression in the vasculature of human COPD lungs and murine model of smoke-induced emphysema
S Reimann, L Fink, J Wilhelm, J Hoffmann, M Bednorz, M Seimetz, ...Respiratory research 16, 1-12, 2015201
42
2015
Functional and muscular adaptations in an experimental model for isometric strength training in mice
K Krüger, DK Gessner, M Seimetz, J Banisch, R Ringseis, K Eder, ...PloS one 8 (11), e79069, 2013201
40
2013
Cigarette smoke-induced emphysema and pulmonary hypertension can be prevented by phosphodiesterase 4 and 5 inhibition in mice
M Seimetz, N Parajuli, A Pichl, M Bednorz, HA Ghofrani, RT Schermuly, ...PLoS One 10 (6), e0129327, 2015201
38
2015
Exercise training reverses inflammation and muscle wasting after tobacco smoke exposure
K Krüger, M Seimetz, R Ringseis, J Wilhelm, A Pichl, A Couturier, K Eder, ...American Journal of Physiology-Regulatory, Integrative and Comparative …, 2018201
35
2018
Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD
J Heidler, A Fysikopoulos, F Wempe, M Seimetz, T Bangsow, ...Disease models & mechanisms 6 (6), 1378-1387, 2013201
34
2013
Rhodiola: An Ordinary Plant or a Promising Future Therapy for Pulmonary Hypertension? A Brief Review
D Kosanovic, X Tian, O Pak, YJ Lai, YL Hsieh, M Seimetz, N Weissmann, ...Pulmonary Circulation 3 (3), 499-506, 2013201
29
2013
Cigarette smoke causes acute airway disease and exacerbates chronic obstructive lung disease in neonatal mice
J Jia, TM Conlon, C Ballester Lopez, M Seimetz, M Bednorz, ...American Journal of Physiology-Lung Cellular and Molecular Physiology 311 (3 …, 2016201
28
2016
Knock out of the NADPH oxidase Nox4 has no impact on life span in mice
F Rezende, C Schürmann, S Schütz, S Harenkamp, E Herrmann, ...Redox biology 11, 312-314, 2017201
27
2017
Riociguat for treatment of pulmonary hypertension in COPD: a translational study
A Pichl, N Sommer, M Bednorz, M Seimetz, S Hadzic, S Kuhnert, S Kraut, ...European Respiratory Journal 53 (6), 2019201
27
2019
Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions
A Tomasovic, N Kurrle, D Sürün, J Heidler, K Husnjak, I Poser, ...Journal of Biological Chemistry 290 (15), 9738-9752, 2015201
25
2015
Chronic obstructive pulmonary disease and the cardiovascular system: vascular repair and regeneration as a therapeutic target
S Karnati, M Seimetz, F Kleefeldt, A Sonawane, T Madhusudhan, ...Frontiers in Cardiovascular Medicine 8, 649512, 2021202
25
2021
NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD
M Seimetz, N Sommer, M Bednorz, O Pak, C Veith, S Hadzic, M Gredic, ...Nature Metabolism 2 (6), 532-546, 2020202
23
2020

Referred From: https://scholar.google.de/citations?user=XIVR4aoAAAAJ&hl=de

Cited by
Citations 1336
h-index 21
i10-index 25
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